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A devastating earthquake struck Aleppo, Syria, killing an estimated 230,000 people and becoming one of the deadliest earthquakes in recorded history

Christopher Columbus's expedition landed in the Bahamas, initially believing they had reached the East Indies, marking the beginning of European exploration of the Americas

Huldrych Zwingli, leader of the Protestant Reformation in Switzerland, was killed at the Battle of Kappel during religious civil wars

General William Howe was named interim commander-in-chief of the British Army in America, replacing Lieutenant General Thomas Gage

The Battle of Valcour Island took place on Lake Champlain, where a British fleet under Sir Guy Carleton defeated American forces led by Benedict Arnold

The Second Boer War began between the British Empire and the Boer republics in South Africa, lasting until 1902

The Second Vatican Council opened in Rome, announced by Pope John XXIII, initiating major reforms in the Catholic Church that lasted three years

Apollo 7, the first manned Apollo mission, launched with astronauts Walter Schirra Jr., Donn Eisele, and Walter Cunningham aboard

Bruce Springsteen's single 'Born to Run' became his first Top 40 hit, launching his transformation from cult figure to international superstar

Former U.S. President Jimmy Carter was awarded the Nobel Peace Prize for his decades of work promoting peace, democracy, and human rights worldwide